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10.1016/j.biotechadv.2007.12.005 93 ShettyS

Despite the absence of specific protocols for cirrhosis patients, sleep diaries are heralded as the gold standard for subjective sleep assessment ( Objective methods for sleep disorders assessment in cirrhosis include the polysomnography test which stands as the gold standard for diagnosing sleep disturbances, but its practicality is hindered by high costs and patient compliance challenges

(2) dissociation of tumor cells from the primary tumor mass, (3) invasion of the neighboring tissue, (4) intravasation into pre-existing and newly formed blood and lymph vessels, (5) transport through the vessels, (6) extravasation from the vessels, (7) establishment of circulating tumor cells (CTCs) and the disseminated cells at a secondary anatomical site, where they can stay dormant for a prolonged period of time, (8) metastatic outgrowth of micrometastases and macrometastases creating clinically detectable secondary tumors and neoplastic process [13]

Baci D, Bruno A, Bassani B, Tramacere M, Mortara L, Albini A, Noonan DM

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